The transport of substrates is one of the main tasks of biomolecular machines in living organisms. We report a synthetic small-molecule system designed to catch, displace, and release molecular cargo in solution under external control. The system consists of a bistable rotaxane that behaves as an acid-base controlled molecular shuttle, whose ring component bears a tether ending with a nitrile group. The latter can be coordinated to a ruthenium complex that acts as the load, and dissociated upon irradiation with visible light. The cargo loading/unloading and ring transfer/return processes are reversible and can be controlled independently. The robust coordination bond ensures that the cargo remains attached to the device while the transport takes place. Nanoscale logistics: We describe a bistable [2]rotaxane shuttle designed to catch, displace, and release molecular cargo in solution under external control. The cargo loading/unloading and ring displacement/return processes are reversible and can be controlled independently with optical and chemical stimuli, respectively. The robust coordination bond ensures that the cargo remains attached to the device during transport.

An Artificial Molecular Transporter

RAGAZZON, GIULIO;LA ROSA, MARCELLO;SILVI, SERENA;CREDI, ALBERTO
2016

Abstract

The transport of substrates is one of the main tasks of biomolecular machines in living organisms. We report a synthetic small-molecule system designed to catch, displace, and release molecular cargo in solution under external control. The system consists of a bistable rotaxane that behaves as an acid-base controlled molecular shuttle, whose ring component bears a tether ending with a nitrile group. The latter can be coordinated to a ruthenium complex that acts as the load, and dissociated upon irradiation with visible light. The cargo loading/unloading and ring transfer/return processes are reversible and can be controlled independently. The robust coordination bond ensures that the cargo remains attached to the device while the transport takes place. Nanoscale logistics: We describe a bistable [2]rotaxane shuttle designed to catch, displace, and release molecular cargo in solution under external control. The cargo loading/unloading and ring displacement/return processes are reversible and can be controlled independently with optical and chemical stimuli, respectively. The robust coordination bond ensures that the cargo remains attached to the device during transport.
Schäfer, Christian; Ragazzon, Giulio; Colasson, Benoit; La Rosa, Marcello; Silvi, Serena; Credi, Alberto
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/562250
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