BACKGROUND/AIMS: To assess the effect of long-term maintenance of steroids on HCV recurrence after liver transplantation (LT), that is still controversial, a prospective multicentre trial was conducted at the centres of Bologna and Padua, Italy. METHODS: From September 2002, 47 eligible HCV positive LT recipients were randomized to receive 2 different steroid schedules in association with tacrolimus: group A: rapid tapering and withdrawal 91 days after LT group B: slow tapering and withdrawal 25 months after LT. Thirty-nine patients were assessable: 23 in group A and 16 in group B. Donor and recipient characteristics were similar in the two groups. Median follow-up was 841 days (130-1376). One hundred liver biopsies were performed, and every patient had a biopsy at month 12. RESULTS: Twenty-two out of 23 (95, 65%) patients in group A and 15 out of 16 (93, 75%) in group B had histologically-confirmed HCV recurrence. Twelve-month histology showed advanced fibrosis (score 3 or 4) in 42.1% of the patients in group A versus 7.6% in group B (P=0.03). One-and 2-year advanced fibrosis-free survival were 65.2 and 60.8 in group A and 93.7% in group B (P=0.03 and =0.02, respectively). CONCLUSIONS: Slow tapering of steroids reduced the progression of recurrent hepatitis C after LT.

Influence of steroids on HCV recurrence after liver transplantation: A prospective study.

VIVARELLI, MARCO;CUCCHETTI, ALESSANDRO;D'ERRICO, ANTONIETTA;GRAZI, GIAN LUCA;PINNA, ANTONIO DANIELE
2007

Abstract

BACKGROUND/AIMS: To assess the effect of long-term maintenance of steroids on HCV recurrence after liver transplantation (LT), that is still controversial, a prospective multicentre trial was conducted at the centres of Bologna and Padua, Italy. METHODS: From September 2002, 47 eligible HCV positive LT recipients were randomized to receive 2 different steroid schedules in association with tacrolimus: group A: rapid tapering and withdrawal 91 days after LT group B: slow tapering and withdrawal 25 months after LT. Thirty-nine patients were assessable: 23 in group A and 16 in group B. Donor and recipient characteristics were similar in the two groups. Median follow-up was 841 days (130-1376). One hundred liver biopsies were performed, and every patient had a biopsy at month 12. RESULTS: Twenty-two out of 23 (95, 65%) patients in group A and 15 out of 16 (93, 75%) in group B had histologically-confirmed HCV recurrence. Twelve-month histology showed advanced fibrosis (score 3 or 4) in 42.1% of the patients in group A versus 7.6% in group B (P=0.03). One-and 2-year advanced fibrosis-free survival were 65.2 and 60.8 in group A and 93.7% in group B (P=0.03 and =0.02, respectively). CONCLUSIONS: Slow tapering of steroids reduced the progression of recurrent hepatitis C after LT.
2007
Vivarelli M; Burra P; Barba GL; Canova D; Senzolo M; Cucchetti A; D'Errico A; Guido M; Merenda R; Neri D; Zanello M; Giannini FM; Grazi GL; Cillo U; Pinna AD.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/55501
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