Pouchitis is the most frequent long-term complication of pouch surgery for ulcerative colitis. There is consistent evidence on the implication of bacterial flora in the pathogenesis of pouchitis, and there is evidence for a therapeutic role of antibiotics and probiotics in therapy of this disease. Antibiotics, particularly ciprofloxacin and metronidazole, are the mainstay of treatment for acute pouchitis. In chronic refractory pouchitis, after having excluded other diagnoses (infections, Crohn's disease of the pouch, ischemia and irritable pouch), antibiotic combination therapy is the treatment of choice. The highly concentrated probiotic mixture VSL#3 has been shown to be effective in prevention of pouchitis onset and in maintaining antibiotic-induced remission.

Gionchetti, P., Calabrese, C., Lauri, A., Rizzello, F. (2015). The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9(9), 1175-1181.

The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis

GIONCHETTI, PAOLO;CALABRESE, CARLO;LAURI, ANDREA;RIZZELLO, FERNANDO
2015

Abstract

Pouchitis is the most frequent long-term complication of pouch surgery for ulcerative colitis. There is consistent evidence on the implication of bacterial flora in the pathogenesis of pouchitis, and there is evidence for a therapeutic role of antibiotics and probiotics in therapy of this disease. Antibiotics, particularly ciprofloxacin and metronidazole, are the mainstay of treatment for acute pouchitis. In chronic refractory pouchitis, after having excluded other diagnoses (infections, Crohn's disease of the pouch, ischemia and irritable pouch), antibiotic combination therapy is the treatment of choice. The highly concentrated probiotic mixture VSL#3 has been shown to be effective in prevention of pouchitis onset and in maintaining antibiotic-induced remission.
2015
Gionchetti, P., Calabrese, C., Lauri, A., Rizzello, F. (2015). The therapeutic potential of antibiotics and probiotics in the treatment of pouchitis. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9(9), 1175-1181.
Gionchetti, P; Calabrese, C; Lauri, A; Rizzello, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/554386
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