A pulsed plasma device “Mather type” Plasma Focus (PFMA-3) has been recently put into operation for a possible application to radiotherapy treatment of malignant cells. Some preliminary data about the better efficiency of PFMA-3 to induce cell damage compared to conventional X-ray devices (XRT) have already been obtained in breast adenocarcinoma cell line MCF-7. To better assess the advantage of the very high dose rate delivered by PFMA-3, we explored its biological effectiveness on a human melanoma cell line SK-Mel28, well known for its radioresistance, in comparison with conventional sources.

Characterization of biological effects in radiotherapy applications of ultra-high dose rate pulses from a plasma focus device

BUONTEMPO, FRANCESCA;ISOLAN, LORENZO;ZIRONI, ISABELLA;CASTELLANI, GASTONE;MOSTACCI, DOMIZIANO;SUMINI, MARCO;MARTELLI, ALBERTO MARIA
2016

Abstract

A pulsed plasma device “Mather type” Plasma Focus (PFMA-3) has been recently put into operation for a possible application to radiotherapy treatment of malignant cells. Some preliminary data about the better efficiency of PFMA-3 to induce cell damage compared to conventional X-ray devices (XRT) have already been obtained in breast adenocarcinoma cell line MCF-7. To better assess the advantage of the very high dose rate delivered by PFMA-3, we explored its biological effectiveness on a human melanoma cell line SK-Mel28, well known for its radioresistance, in comparison with conventional sources.
Proceedings of the 24th Biennial Congress of the European Association for Cancer Research - EACR24, European Journal of Cancer, Vol. 61, Suppl. 1, July 2016
S159
S159
Buontempo, F.; Isolan, L.; Zironi, I.; Castellani, G.; Nano, R.; Pasi, F.; Tartari, A.; Mostacci, D.; Sumini, M.; Martelli, A.M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/553005
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