A pulsed plasma device “Mather type” Plasma Focus (PFMA-3) has been recently put into operation for a possible application to radiotherapy treatment of malignant cells. Some preliminary data about the better efficiency of PFMA-3 to induce cell damage compared to conventional X-ray devices (XRT) have already been obtained in breast adenocarcinoma cell line MCF-7. To better assess the advantage of the very high dose rate delivered by PFMA-3, we explored its biological effectiveness on a human melanoma cell line SK-Mel28, well known for its radioresistance, in comparison with conventional sources.
Buontempo, F., Isolan, L., Zironi, I., Castellani, G., Nano, R., Pasi, F., et al. (2016). Characterization of biological effects in radiotherapy applications of ultra-high dose rate pulses from a plasma focus device. Elsevier.
Characterization of biological effects in radiotherapy applications of ultra-high dose rate pulses from a plasma focus device
BUONTEMPO, FRANCESCA;ISOLAN, LORENZO;ZIRONI, ISABELLA;CASTELLANI, GASTONE;MOSTACCI, DOMIZIANO;SUMINI, MARCO;MARTELLI, ALBERTO MARIA
2016
Abstract
A pulsed plasma device “Mather type” Plasma Focus (PFMA-3) has been recently put into operation for a possible application to radiotherapy treatment of malignant cells. Some preliminary data about the better efficiency of PFMA-3 to induce cell damage compared to conventional X-ray devices (XRT) have already been obtained in breast adenocarcinoma cell line MCF-7. To better assess the advantage of the very high dose rate delivered by PFMA-3, we explored its biological effectiveness on a human melanoma cell line SK-Mel28, well known for its radioresistance, in comparison with conventional sources.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
