Patients with atopic eczema present higher serum levels of total IgE and different pattern of cytokines, compared to nonatopic eczematous patients. This study aimed to evaluate serum levels of IL-2, IL-4, IL-5, IL-10, IFNγ, TNFα in eczematous children in relation to atopic and nonatopic form. We enrolled 45 eczematous children and 12 controls. Total IgE and specific IgE against principal food and inhalant allergens were evaluated by UniCap1000 and levels of cytokines by Cytometric Bead Array System. The geometric means of levels of IL-4 were higher in eczematous patients than controls (P=0.036). Serum levels of IL-10 and IFNγ were higher in nonatopic eczematous children than in atopic eczematous patients and controls (P= 0.004, P= 0.003). Our data confirm that cytokines may play an important role in the pathogenesis of eczema: nonatopic eczema seems to be characterized by increased levels of IL-10 and IFNγ compared to atopic form.
Cytokines levels in children affected by atopic and nonatopic eczema / G. Ricci; A. Patrizi; F. Bellini; E. Calamelli; V. Dell’Omo; B. Bendandi; M. Masi. - In: THE OPEN DERMATOLOGY JOURNAL. - ISSN 1874-3722. - ELETTRONICO. - 2:(2008), pp. 18-21. [10.2174/1874372200802010018]
Cytokines levels in children affected by atopic and nonatopic eczema.
RICCI, GIAMPAOLO;PATRIZI, ANNALISA;BELLINI, FEDERICA;CALAMELLI, ELISABETTA;DELL'OMO, VALERIA;BENDANDI, BARBARA;MASI, MASSIMO
2008
Abstract
Patients with atopic eczema present higher serum levels of total IgE and different pattern of cytokines, compared to nonatopic eczematous patients. This study aimed to evaluate serum levels of IL-2, IL-4, IL-5, IL-10, IFNγ, TNFα in eczematous children in relation to atopic and nonatopic form. We enrolled 45 eczematous children and 12 controls. Total IgE and specific IgE against principal food and inhalant allergens were evaluated by UniCap1000 and levels of cytokines by Cytometric Bead Array System. The geometric means of levels of IL-4 were higher in eczematous patients than controls (P=0.036). Serum levels of IL-10 and IFNγ were higher in nonatopic eczematous children than in atopic eczematous patients and controls (P= 0.004, P= 0.003). Our data confirm that cytokines may play an important role in the pathogenesis of eczema: nonatopic eczema seems to be characterized by increased levels of IL-10 and IFNγ compared to atopic form.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
