Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
Fiume, R., Jones, D.R., Divecha, N. (2016). PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis. TRENDS IN BIOCHEMICAL SCIENCES, 41(6), 473-475 [10.1016/j.tibs.2016.04.003].
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis
FIUME, ROBERTA;
2016
Abstract
Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.File in questo prodotto:
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