Perianal Crohn’s disease represents one of the most devastating conditions for Crohn’s patients [1]. Fistulizing features can be seen in around 90 % of patients with perianal Crohn’s disease [2]. The treatment of such fistulas is a challenging task for surgeons due to high recurrence rate. Endorectal advancement flap is one of the best choices to treat high and complex Crohn’s fistulas in a background of rectal sparing disease or healed mucosa post-biological therapy. The reported success rate of endorectal advancement flap in Crohn’s fistulas is 64 % [3]. Ozone (O3) has been used as a healing promoter for diabetic ulcers, trophic and ischemic ulcers as well as other types of chronic wounds. Increment of oxygen tension in the wound area and the bactericidal, antiviral and antifungal characteristics of ozone (O3) encourage its use as wound-healing accelerator [4]. Olive oil is one of the best reservoirs for ozone due to its ability to stabilize O3 between the double bonds of unsaturated fatty acids [4]. Ozonized olive oil-based medication NOVOX® (MOSS SpA, Lesa, Novara, Italy) comes in an oily gel form in a sealed syringe. The aim of this study is to assess the effect of NOVOX® in Crohn’s patients with persistent tracts as a result of minor endorectal advancement flap dehiscence.

Treatment of minor dehiscence after endorectal advancement flap in perianal Crohn's fistulas with ozonized oil NOVOX(®) / Laureti, S; Aborajooh, E; Mattioli, B; Poggioli, G. - In: TECHNIQUES IN COLOPROCTOLOGY. - ISSN 1123-6337. - STAMPA. - 20:2(2016), pp. 139-140. [10.1007/s10151-015-1404-4]

Treatment of minor dehiscence after endorectal advancement flap in perianal Crohn's fistulas with ozonized oil NOVOX(®)

LAURETI, SILVIO;MATTIOLI, BENEDETTA;POGGIOLI, GILBERTO
2016

Abstract

Perianal Crohn’s disease represents one of the most devastating conditions for Crohn’s patients [1]. Fistulizing features can be seen in around 90 % of patients with perianal Crohn’s disease [2]. The treatment of such fistulas is a challenging task for surgeons due to high recurrence rate. Endorectal advancement flap is one of the best choices to treat high and complex Crohn’s fistulas in a background of rectal sparing disease or healed mucosa post-biological therapy. The reported success rate of endorectal advancement flap in Crohn’s fistulas is 64 % [3]. Ozone (O3) has been used as a healing promoter for diabetic ulcers, trophic and ischemic ulcers as well as other types of chronic wounds. Increment of oxygen tension in the wound area and the bactericidal, antiviral and antifungal characteristics of ozone (O3) encourage its use as wound-healing accelerator [4]. Olive oil is one of the best reservoirs for ozone due to its ability to stabilize O3 between the double bonds of unsaturated fatty acids [4]. Ozonized olive oil-based medication NOVOX® (MOSS SpA, Lesa, Novara, Italy) comes in an oily gel form in a sealed syringe. The aim of this study is to assess the effect of NOVOX® in Crohn’s patients with persistent tracts as a result of minor endorectal advancement flap dehiscence.
2016
Treatment of minor dehiscence after endorectal advancement flap in perianal Crohn's fistulas with ozonized oil NOVOX(®) / Laureti, S; Aborajooh, E; Mattioli, B; Poggioli, G. - In: TECHNIQUES IN COLOPROCTOLOGY. - ISSN 1123-6337. - STAMPA. - 20:2(2016), pp. 139-140. [10.1007/s10151-015-1404-4]
Laureti, S; Aborajooh, E; Mattioli, B; Poggioli, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/551397
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