Osteoporosis is a disease characterized by loss of bone tissue, with alterations of bone mineral density (BMD) and architecture, leading to high risk of bone fractures. Dual X-rays Absorptiometry is the gold standard technique. Although the importance of bone microarchitecture in addition to BMD has been emphasized it is not measured with dual X-rays Absorptiometry. On the contrary, NMR (including MRI) and Micro-Computed Tomography (µCT) techniques are able to assess bone microarchitecture information. Here we propose NMR methods for the assessment of bone microarchitecture, based on the use of mobile single-sided devices. The profile NMR-MOUSE PM10 (Magritek) and the NMR MOLE, both being portable low field NMR systems, have been used. Here we report the first results obtained on cylindrical animal bone samples which may serve as models for human fingers. Acquired NMR signals of the samples have been normalized to the signal of pure marrow samples, in order to determine the Bone volume/Total volume ratio (BV/TV). The results have been compared with BV/TV obtained by µCT (Skyscan 1072) and good agreement to the MOUSE results has been found. The authors thank the Fondazione del Monte di Bologna e Ravenna for the support to this project.
The use of mobile single-sided NMR for the diagnosis of osteoporosis: a preliminary study
BORTOLOTTI, VILLIAM;BRIZI, LEONARDO;FANTAZZINI, PAOLA;
2015
Abstract
Osteoporosis is a disease characterized by loss of bone tissue, with alterations of bone mineral density (BMD) and architecture, leading to high risk of bone fractures. Dual X-rays Absorptiometry is the gold standard technique. Although the importance of bone microarchitecture in addition to BMD has been emphasized it is not measured with dual X-rays Absorptiometry. On the contrary, NMR (including MRI) and Micro-Computed Tomography (µCT) techniques are able to assess bone microarchitecture information. Here we propose NMR methods for the assessment of bone microarchitecture, based on the use of mobile single-sided devices. The profile NMR-MOUSE PM10 (Magritek) and the NMR MOLE, both being portable low field NMR systems, have been used. Here we report the first results obtained on cylindrical animal bone samples which may serve as models for human fingers. Acquired NMR signals of the samples have been normalized to the signal of pure marrow samples, in order to determine the Bone volume/Total volume ratio (BV/TV). The results have been compared with BV/TV obtained by µCT (Skyscan 1072) and good agreement to the MOUSE results has been found. The authors thank the Fondazione del Monte di Bologna e Ravenna for the support to this project.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
