Alterations of brain-derived neurotrophic factor (BDNF) have been associated with the development of addiction to different drugs of abuse, including ethanol (EtOH). EtOH exposure activates the BDNF-signaling cascade in dorsal striatum, which in turn affects further EtOH intake. Different alcohol exposures have been widely demonstrated to modulate chromatin remodeling, affecting histone acetylation/deacetylation balance. Recently, class I histone deacetylases (HDACs) inhibition has been reported to modulate BDNF mRNA expression and to attenuate morphological and behavioral phenomena related to EtOH exposure. However, the role played by different HDAC isoforms in EtOH-induced plasticity is still unclear.
Caputi, F.F., Palmisano, M., D'Addario, C., Candeletti, S., Romualdi, P. (2015). Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice. DRUG AND ALCOHOL DEPENDENCE, 155, 68-75 [10.1016/j.drugalcdep.2015.08.015].
Effects of acute ethanol exposure on class I HDACs family enzymes in wild-type and BDNF(+/-) mice
CAPUTI, FRANCESCA FELICIA;PALMISANO, MARTINA;CANDELETTI, SANZIO;ROMUALDI, PATRIZIA
2015
Abstract
Alterations of brain-derived neurotrophic factor (BDNF) have been associated with the development of addiction to different drugs of abuse, including ethanol (EtOH). EtOH exposure activates the BDNF-signaling cascade in dorsal striatum, which in turn affects further EtOH intake. Different alcohol exposures have been widely demonstrated to modulate chromatin remodeling, affecting histone acetylation/deacetylation balance. Recently, class I histone deacetylases (HDACs) inhibition has been reported to modulate BDNF mRNA expression and to attenuate morphological and behavioral phenomena related to EtOH exposure. However, the role played by different HDAC isoforms in EtOH-induced plasticity is still unclear.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
