Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing effects of MSCs are mainly related to unique paracrine properties, opening opportunities for secretome-based therapies. Apart from soluble factors, MSCs release functional small RNAs via extracellular vesicles (EVs) that seem to convey essential features of MSCs. Here we set out to characterize the full small RNAome of MSC-produced exosomes.
Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species / Baglio, Serena Rubina; Rooijers, Koos; Koppers-Lalic, Danijela; Verweij, Frederik J; Pérez Lanzón, M; Zini, Nicoletta; Naaijkens, Benno; Perut, Francesca; Niessen, Hans W M; Baldini, Nicola; Pegtel, D Michiel. - In: STEM CELL RESEARCH & THERAPY. - ISSN 1757-6512. - ELETTRONICO. - 6:(2015), pp. 127.1-127.20. [10.1186/s13287-015-0116-z]
Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
PERUT, FRANCESCA;BALDINI, NICOLA;
2015
Abstract
Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological and degenerative disorders. Accumulating evidence indicates that the healing effects of MSCs are mainly related to unique paracrine properties, opening opportunities for secretome-based therapies. Apart from soluble factors, MSCs release functional small RNAs via extracellular vesicles (EVs) that seem to convey essential features of MSCs. Here we set out to characterize the full small RNAome of MSC-produced exosomes.| File | Dimensione | Formato | |
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