BACKGROUND: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). OBJECTIVES: The CoSMo study evaluated the association between CCSVI and MS. METHODS: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. RESULTS: The study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. CONCLUSIONS: CCSVI is not associated with MS.
Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study / G. Comi; M. Battaglia; A. Bertolotto; M. D. Sette; A. Ghezzi; G. Malferrari; M. Salvetti; M. Sormani; L. Tesio; E. Stolz; P. Zaratin; G. Mancardi; A. CoSMo Collaborative Study group [; Alessandra Lugaresi; A. Protti; A. Ciuffoli; A. Bratina; A. Ghezzi; A. Guccione; A. Deboni; A. Bertolotto; B. Giometto; C. Finocchi; C. Baracchini; D. Maimone; D. Rossato; D. Centonze; D. Ciampanelli; E. Favaretto; E. Menci; E. Granieri; E. Sanzaro; F. Viaro; F. Bortolon; F. Iemolo; F. Patti; F. Tezzon; G. Comi; G. Costantino; G. L. Mancardi; G. Malferrari; G. Sette; G. M. Nuzzaco; L. Provinciali; L. Coppo; L. D. Maggio; L. Monti; L. Pascazio; L. Grimaldi; L. Motti; M. Mancini; M. Busso; M. Rovaris; M. Salvetti; M. Buccafusca; M. L. Zedde; M. R. Tola; M. Trojano; M. Spinelli; M. D. Sette; M. Stefanini; M. Cirrito; M. Ulivelli; N. Carraro; N. D. Rossi; P. Cavalla; P. Zaratin; P. Gallo; P. Lochner; P. Cecconi; R. Mantegazza; R. Gaeta; R. Bergamaschi; R. Capra; S. Cottone; S. Sanguigni; S. Stecchi; S. Grazioli; S. Tonello; V. B. Morra]. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - STAMPA. - 19:11(2013), pp. 1508-1517. [10.1177/1352458513501231]
Observational case-control study of the prevalence of chronic cerebrospinal venous insufficiency in multiple sclerosis: results from the CoSMo study
LUGARESI, ALESSANDRA;
2013
Abstract
BACKGROUND: Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a possible cause of multiple sclerosis (MS). OBJECTIVES: The CoSMo study evaluated the association between CCSVI and MS. METHODS: The primary end-point of this multicentric, case-control study was to compare the prevalence of CCSVI between patients with MS, patients with other neurodegenerative diseases (ONDs) and healthy controls (HCs). Color-coded duplex sonography was performed by a sonologist and the images were sent to one of three central sonologists for a second reading. Agreement between local and central sonologists or, in case of disagreement, the predominant judgment among the three central readers, was required for a diagnosis of CCSVI. All readings, data collection and analysis were blinded. RESULTS: The study involved 35 MS centers across Italy and included 1874 subjects aged 18-55. 1767 (94%) were evaluable: 1165 MS patients, 226 patients with ONDs and 376 HCs. CCSVI prevalence was 3.26%, 3.10% and 2.13% for the MS, OND and HC groups, respectively. No significant difference in CCSVI prevalence was found amongst the three cohorts (MS versus HC, OR = 1.55, 95%CI = 0.72-3.36, p = 0.30; OND versus HC, OR = 1.47, 95%CI = 0.53-4.11, p = 0.46; MS versus OND, OR = 1.05, 95%CI = 0.47-2.39, p = 0.99). High negative and low positive agreement was found between the local and centralized readers. CONCLUSIONS: CCSVI is not associated with MS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
