Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry. Methods Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scores
The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry / Hughes S; Spelman T; Trojano M; Lugaresi A; Izquierdo G; Grand'maison F; Duquette P; Girard M; Grammond P; Oreja-Guevara C; Hupperts R; Boz C; Bergamaschi R; Giuliani G; Rio ME; Lechner-Scott J; van Pesch V; Iuliano G; Fiol M; Verheul F; Barnett M; Slee M; Herbert J; Kister I; Vella N; Moore F; Petkovska-Boskova T; Shaygannejad V; Jokubaitis V; McDonnell G; Hawkins S; Kee F; Gray O; Butzkueven H; on behalf of the MSBase Study Group; FArina D; De Luca G; Pietrolongo E; di Ioia M; Di Tommaso V; Travaglini D. - In: JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY. - ISSN 0022-3050. - STAMPA. - 83:(2012), pp. 305-310. [10.1136/jnnp-2011-301051]
The Kurtzke EDSS rank stability increases 4 years after the onset of multiple sclerosis: results from the MSBase Registry.
LUGARESI, ALESSANDRA;
2012
Abstract
Background The Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires validation in longitudinal cohorts, we aimed to assess the utility of EDSS ranking as a predictor of 5-year outcome in the MSBase Registry. Methods Rank stability of EDSS over time was examined in the MSBase Registry, a large multicentre MS cohort. Scores were ranked for 5-year intervals, and correlation of rank across intervals was assessed using Spearman's rank correlation. EDSS progression outcomes at 10 years were disaggregated by 5-year EDSS scoresI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
