Maternal parasitoses modulate fetal immune development, manifesting as altered cellular immunological activity in cord blood that may be linked to enhanced susceptibility to infections in early life. Plasmodium falciparum typifies such infections, with distinct placental infection-related changes in cord blood exemplified by expanded populations of parasite antigen-specific regulatory T cells. Here we addressed whether such early-onset cellular immunological alterations persist through infancy. Specifically, in order to assess the potential impacts of P. falciparum infections either during pregnancy or during infancy, we quantified lymphocyte subsets in cord blood and in infants' peripheral blood during the first year of life. The principal age-related changes observed, independent of infection status, concerned decreases in the frequencies of CD4+, NKdim and NKT cells, whilst CD8+, Treg and Teff cells' frequencies increased from birth to 12 months of age. P. falciparum infections present at delivery, but not those earlier in gestation, were associated with increased frequencies of Treg and CD8+ T cells but fewer CD4+ and NKT cells during infancy, thus accentuating the observed age-related patterns. Overall, P. falciparum infections arising during infancy were associated with a reversal of the trends associated with maternal infection i.e. with more CD4+ cells, with fewer Treg and CD8+ cells. We conclude that maternal P. falciparum infection at delivery has significant and, in some cases, year-long effects on the composition of infants' peripheral blood lymphocyte populations. Those effects are superimposed on separate and independent age- as well as infant infection-related alterations that, respectively, either match or run counter to them.

Nouatin, O., Gbédandé, K., Ibitokou, S., Vianou, B., Houngbegnon, P., Ezinmegnon, S., et al. (2015). Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum. PLOS ONE, 10(11), 1-23 [10.1371/journal.pone.0139606].

Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum

VARANI, STEFANIA;
2015

Abstract

Maternal parasitoses modulate fetal immune development, manifesting as altered cellular immunological activity in cord blood that may be linked to enhanced susceptibility to infections in early life. Plasmodium falciparum typifies such infections, with distinct placental infection-related changes in cord blood exemplified by expanded populations of parasite antigen-specific regulatory T cells. Here we addressed whether such early-onset cellular immunological alterations persist through infancy. Specifically, in order to assess the potential impacts of P. falciparum infections either during pregnancy or during infancy, we quantified lymphocyte subsets in cord blood and in infants' peripheral blood during the first year of life. The principal age-related changes observed, independent of infection status, concerned decreases in the frequencies of CD4+, NKdim and NKT cells, whilst CD8+, Treg and Teff cells' frequencies increased from birth to 12 months of age. P. falciparum infections present at delivery, but not those earlier in gestation, were associated with increased frequencies of Treg and CD8+ T cells but fewer CD4+ and NKT cells during infancy, thus accentuating the observed age-related patterns. Overall, P. falciparum infections arising during infancy were associated with a reversal of the trends associated with maternal infection i.e. with more CD4+ cells, with fewer Treg and CD8+ cells. We conclude that maternal P. falciparum infection at delivery has significant and, in some cases, year-long effects on the composition of infants' peripheral blood lymphocyte populations. Those effects are superimposed on separate and independent age- as well as infant infection-related alterations that, respectively, either match or run counter to them.
2015
Nouatin, O., Gbédandé, K., Ibitokou, S., Vianou, B., Houngbegnon, P., Ezinmegnon, S., et al. (2015). Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum. PLOS ONE, 10(11), 1-23 [10.1371/journal.pone.0139606].
Nouatin, Odilon; Gbédandé, Komi; Ibitokou, Samad; Vianou, Bertin; Houngbegnon, Parfait; Ezinmegnon, Sem; Borgella, Sophie; Akplogan, Carine; Cottrell,...espandi
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Descrizione: S1 Fig: The gating strategies for Treg (CD4+CD25+CD127-) and Teff (CD4+CD25+CD127+). Cell frequencies were determined as a percentage from the whole lymphocyte population, and relative FoxP3 expression level determined as a function of FoxP3 expresssion by naïve CD4+ T cells (CD4+CD25-).
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Descrizione: S1 Table: Univariate analysis of alterations in circulating T- and NK-cell subset frequencies in cord/infant blood as a function of P. falciparum infection detected either in the mother at delivery or during infancy
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/546167
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