Alkynyl(triphenylphosphine)gold(I) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7–7.9 μM).

Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes

DE NISI, ASSUNTA
Methodology
;
BERGAMINI, CHRISTIAN
Methodology
;
SARTOR, GIORGIO
Methodology
;
FATO, ROMANA
Conceptualization
;
NALDI, MARINA
Methodology
;
MONARI, MAGDA
Conceptualization
;
CALONGHI, NATALIA
Conceptualization
;
BANDINI, MARCO
Writing – Original Draft Preparation
2016

Abstract

Alkynyl(triphenylphosphine)gold(I) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7–7.9 μM).
De Nisi, Assunta; Bergamini, Christian; Leonzio, Marco; Sartor, Giorgio; Fato, Romana; Naldi, Marina; Monari, Magda; Calonghi, Natalia; Bandini, Marco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/545974
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