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EnglishPurpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
| Titolo: | Efficacy of radioembolization according to tumor morphology and portal vein thrombosis inintermediate-advanced hepatocellular carcinoma |
| Autore/i: | GOLFIERI, RITA; MOSCONI, CRISTINA; Cappelli, Alberta; Giampalma, Emanuela; Galaverni, Maria Cristina; Pettinato, Cinzia; RENZULLI, MATTEO; Monari, Fabio; Angelelli, Bruna; Pini, Patrizia; TERZI, ELEONORA; Ascanio, Salvatore; Garzillo, Giorgio; PISCAGLIA, FABIO; BOLONDI, LUIGI; TREVISANI, FRANCO |
| Autore/i Unibo: | |
| Anno: | 2015 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2217/fon.15.267 |
| Abstract: | Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types. |
| Data stato definitivo: | 2016-06-29T16:31:20Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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