Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
Efficacy of radioembolization according to tumor morphology and portal vein thrombosis inintermediate-advanced hepatocellular carcinoma / Golfieri, Rita; Mosconi, Cristina; Cappelli, Alberta; Giampalma, Emanuela; Galaverni, Maria Cristina; Pettinato, Cinzia; Renzulli, Matteo; Monari, Fabio; Angelelli, Bruna; Pini, Patrizia; Terzi, Eleonora; Ascanio, Salvatore; Garzillo, Giorgio; Piscaglia, Fabio; Bolondi, Luigi; Trevisani, Franco. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - ELETTRONICO. - 11:23(2015), pp. 3133-3142. [10.2217/fon.15.267]
Efficacy of radioembolization according to tumor morphology and portal vein thrombosis inintermediate-advanced hepatocellular carcinoma
GOLFIERI, RITA;MOSCONI, CRISTINA;RENZULLI, MATTEO;TERZI, ELEONORA;PISCAGLIA, FABIO;BOLONDI, LUIGI;TREVISANI, FRANCO
2015
Abstract
Purpose: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). Methods: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. Results: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. Conclusion: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
