Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.

Cimmino A., Calin G. A., Fabbri M., Iorio M. V., Ferracin M., Shimizu M., et al. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 13944-13949 [10.1073/pnas.0506654102].

miR-15 and miR-16 induce apoptosis by targeting BCL2

FERRACIN, MANUELA;
2005

Abstract

Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
2005
Cimmino A., Calin G. A., Fabbri M., Iorio M. V., Ferracin M., Shimizu M., et al. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102, 13944-13949 [10.1073/pnas.0506654102].
Cimmino A.; Calin G. A.; Fabbri M.; Iorio M. V.; Ferracin M.; Shimizu M.; Wojcik S. E.; Aqeilan R. I.; Zupo S.; Dono M.; Rassenti L.; Alder H.; Volini...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/542241
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