2-Oxazolidinone (systematic name 1,3-oxazolidin-2-one) is a five-member heterocyclic ring exhibiting potential medicinal roperties. It is the pharmacophore of a class of antimicrobial agents which have a unique structure and good activity gainst Gram-positive pathogenic bacteria (e.g. linezolid, the first in clinical use 2-oxazolidinone antibiotic). Often the functionality of drugs is related to their conformational flexibility and ability to form non covalent interactions with ts urroundings. In order to understand how substitution affect these properties, a series of oxazolidone compounds has been studied by means of millimeter wave free jet Stark modulated absorption spectroscopy [1] and quantum mechanical calculations. The achieved data will be presented. [1] C. Calabrese, A. Maris, L. Evangelisti, L.B. Favero, S. Melandri and W. Caminati, J. Phys. Chem. A, 117, 13712 (2013).

Free jet millimeter wave spectroscopy of oxazolidinone compounds.

MARIS, ASSIMO;MELANDRI, SONIA;CALABRESE, CAMILLA;VIGORITO, ANNALISA;
2014

Abstract

2-Oxazolidinone (systematic name 1,3-oxazolidin-2-one) is a five-member heterocyclic ring exhibiting potential medicinal roperties. It is the pharmacophore of a class of antimicrobial agents which have a unique structure and good activity gainst Gram-positive pathogenic bacteria (e.g. linezolid, the first in clinical use 2-oxazolidinone antibiotic). Often the functionality of drugs is related to their conformational flexibility and ability to form non covalent interactions with ts urroundings. In order to understand how substitution affect these properties, a series of oxazolidone compounds has been studied by means of millimeter wave free jet Stark modulated absorption spectroscopy [1] and quantum mechanical calculations. The achieved data will be presented. [1] C. Calabrese, A. Maris, L. Evangelisti, L.B. Favero, S. Melandri and W. Caminati, J. Phys. Chem. A, 117, 13712 (2013).
2014
Book of abstracts - The 23th International Conference on High Resolution Molecular Spectroscopy
155
155
Maris, A.; Melandri, S.; Calabrese, C.; Vigorito, A.; Favero, L.B.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/541692
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