AIM: Porphyrin-loaded core-shell nanoparticles have been engineered for use as in vivo sonosensitizing systems, radio-tracers or magnetic resonance (MR) imaging agents, which may be suitable for the selective treatment of solid tumors and imaging analyses. MATERIALS & METHODS: Polymethyl methacrylate nanoparticles (PMMANPs) have been either loaded with meso-tetrakis (4-sulphonatophenyl) porphyrin (TPPS) for sonodynamic anticancer treatment, with (64)Cu-TPPS for positron emission tomography biodistribution studies or with Mn(III)-TPPS for MR tumor accumulation evaluation. RESULTS: PMMANPs are easily functionalized with negatively charged molecules and show favorable biodistribution. In vivo TPPS-PMMANPs have demonstrated shock wave responsiveness in a Mat B III syngeneic rat breast cancer model as measured by MR analyses of pre- and post-treatment tumor volumes. CONCLUSION: TPPS-PMMANPs are a multimodal system which can efficiently induce in vivo sonodynamic anticancer activity. KEYWORDS: acoustic cavitation; cancer; polymethyl methacrylate nanoparticles; porphyrin; reactive oxygen species; shock waves; sonodynamic therapy; sonosensitizer; theranostics; therapeutic ultrasound
Varchi G, Foglietta F, Canaparo R, Ballestri M, Arena F, Sotgiu G, et al. (2015). Engineered porphyrin loaded core-shell nanoparticles for selective sonodynamic anticancer treatment. NANOMEDICINE, 10, 3483-3494 [10.2217/nnm.15.150].
Engineered porphyrin loaded core-shell nanoparticles for selective sonodynamic anticancer treatment.
FANTI, STEFANO;
2015
Abstract
AIM: Porphyrin-loaded core-shell nanoparticles have been engineered for use as in vivo sonosensitizing systems, radio-tracers or magnetic resonance (MR) imaging agents, which may be suitable for the selective treatment of solid tumors and imaging analyses. MATERIALS & METHODS: Polymethyl methacrylate nanoparticles (PMMANPs) have been either loaded with meso-tetrakis (4-sulphonatophenyl) porphyrin (TPPS) for sonodynamic anticancer treatment, with (64)Cu-TPPS for positron emission tomography biodistribution studies or with Mn(III)-TPPS for MR tumor accumulation evaluation. RESULTS: PMMANPs are easily functionalized with negatively charged molecules and show favorable biodistribution. In vivo TPPS-PMMANPs have demonstrated shock wave responsiveness in a Mat B III syngeneic rat breast cancer model as measured by MR analyses of pre- and post-treatment tumor volumes. CONCLUSION: TPPS-PMMANPs are a multimodal system which can efficiently induce in vivo sonodynamic anticancer activity. KEYWORDS: acoustic cavitation; cancer; polymethyl methacrylate nanoparticles; porphyrin; reactive oxygen species; shock waves; sonodynamic therapy; sonosensitizer; theranostics; therapeutic ultrasoundI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
