BACKGROUND: Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. AIMS: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. METHOD: Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression). RESULTS: A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. CONCLUSIONS: Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.
Physical exercise for late-life major depression / Belvederi Murri, M.; Amore, M.; Menchetti, M.; Toni, G.; Neviani, F.; Cerri, M.; Rocchi, M.B.L.; Zocchi, D.; Bagnoli, L.; Tam, E.; Buffa, A.; Ferrara, S.; Neri, M.; Alexopoulos, G.S.; Zanetidou, S.. - In: BRITISH JOURNAL OF PSYCHIATRY. - ISSN 0007-1250. - STAMPA. - 207:3(2015), pp. 235-242. [10.1192/bjp.bp.114.150516]
Physical exercise for late-life major depression
BELVEDERI MURRI, MARTINO;CERRI, MATTEO;ZOCCHI, DONATO;TAM, ENRICO;BUFFA, ANGELA;FERRARA, SABRINA;ZANETIDOU, STAMATULA
2015
Abstract
BACKGROUND: Interventions including physical exercise may help improve the outcomes of late-life major depression, but few studies are available. AIMS: To investigate whether augmenting sertraline therapy with physical exercise leads to better outcomes of late-life major depression. METHOD: Primary care patients (465 years) with major depression were randomised to 24 weeks of higher-intensity, progressive aerobic exercise plus sertraline (S+PAE), lower-intensity, non-progressive exercise plus sertraline (S+NPE) and sertraline alone. The primary outcome was remission (a score of ≤10 on the Hamilton Rating Scale for Depression). RESULTS: A total of 121 patients were included. At study end, 45% of participants in the sertraline group, 73% of those in the S+NPE group and 81% of those in the S+PAE group achieved remission (P = 0.001). A shorter time to remission was observed in the S+PAE group than in the sertraline-only group. CONCLUSIONS: Physical exercise may be a safe and effective augmentation to antidepressant therapy in late-life major depression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
