The presence of leukocytes in platelet concentrates is deemed to cause deleterious effects when injected intra articularly. The aim of this study is to analyse both local and systemic effects induced by leukocyte-rich Platelet-rich Plasma (PRP) injections through a proteomic characterization of serial synovial fluid and blood samples obtained from subjects treated for knee OA. Secondary aim was to compare the effects on knee homeostasis and systemic response with those obtained with visco-supplementation.
Mariani, E., Canella, V., Cattini, L., Kon, E., Marcacci, M., Di Matteo, B., et al. (2016). Leukocyte-Rich Platelet-Rich Plasma Injections Do Not Up-Modulate Intra-Articular Pro-Inflammatory Cytokines in the Osteoarthritic Knee. PLOS ONE, 11(6), 1-13 [10.1371/journal.pone.0156137].
Leukocyte-Rich Platelet-Rich Plasma Injections Do Not Up-Modulate Intra-Articular Pro-Inflammatory Cytokines in the Osteoarthritic Knee
MARIANI, ERMINIA;KON, ELIZAVETA;MARCACCI, MAURILIO;DI MATTEO, BERARDO;FILARDO, GIUSEPPE
2016
Abstract
The presence of leukocytes in platelet concentrates is deemed to cause deleterious effects when injected intra articularly. The aim of this study is to analyse both local and systemic effects induced by leukocyte-rich Platelet-rich Plasma (PRP) injections through a proteomic characterization of serial synovial fluid and blood samples obtained from subjects treated for knee OA. Secondary aim was to compare the effects on knee homeostasis and systemic response with those obtained with visco-supplementation.| File | Dimensione | Formato | |
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pone.0156137.s001.pdf
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Descrizione: S1 File: Study Trial Protocol (English Translation)
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pone.0156137.s002.pdf
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pone.0156137.s003.xlsx
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Descrizione: S3 File: Concentration of the evaluated molecules, in both treatment groups (all patients’data)
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