Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. PATIENTS AND METHODS: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. RESULTS: Two hundred and thirty-two patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. CONCLUSION: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.

The effect of re-operation on survival in patients with recurrent glioblastoma

FRANCESCHI, ENRICO;BARTOLOTTI, MARCO;STURIALE, CARMELO;POZZATI, EUGENIO;MORANDI, LUCA;
2015

Abstract

Treatment options for glioblastoma (GBM) at recurrence have limited efficacy. Re-surgery has been used for confirmation of recurrent disease and to provide relief of symptoms but the real impact on survival is unknown. PATIENTS AND METHODS: A retrospective analysis was performed for GBM patients followed between 01/2005 and 06/2010 at our Institution. RESULTS: Two hundred and thirty-two patients with recurrent GBM were evaluated. One hundred and two patients (44%) were treated with re-surgery followed by chemotherapy and 130 patients (56%) with chemotherapy alone. In multivariate analysis, no significant effect of re-surgery was found, with age (p=0.001), MGMT methylation (p=0.002) and PFS at 6 months (p=0.0001) being significant prognostic factors. CONCLUSION: Second surgery might have a limited impact in the clinical course of recurrent GBM patients.
2015
Franceschi, Enrico; Bartolotti, Marco; Tosoni, Alicia; Bartolini, Stefania; Sturiale, Carmelo; Fioravanti, Antonio; Pozzati, Eugenio; Galzio, Renato; Talacchi, Andrea; Volpin, Lorenzo; Morandi, Luca; Danieli, Daniela; Ermani, Mario; Brandes, Alba A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/529557
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