Stereoselective synthesis of unnatural tetrapeptides containing two L-valine units and two unnatural alpha-amino acids (ornithine and modified aspartic acid), has been accomplished starting from a L-valine derived chiral synthon. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H-NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis.
G. M. Almiento, D. Balducci, A. Bottoni, M. Calvaresi, G. Porzi (2007). Stereoselective synthesis and conformational analysis of unnatural tetrapeptides. Part 2. TETRAHEDRON-ASYMMETRY, 18, 2695-2711 [10.1016/j.tetasy.2007.10.038].
Stereoselective synthesis and conformational analysis of unnatural tetrapeptides. Part 2
BALDUCCI, DANIELE;BOTTONI, ANDREA;CALVARESI, MATTEO;PORZI, GIANNI
2007
Abstract
Stereoselective synthesis of unnatural tetrapeptides containing two L-valine units and two unnatural alpha-amino acids (ornithine and modified aspartic acid), has been accomplished starting from a L-valine derived chiral synthon. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H-NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
