Stereoselective synthesis of unnatural tetrapeptides containing two L-valine units and two unnatural alpha-amino acids (ornithine and modified aspartic acid), has been accomplished starting from a L-valine derived chiral synthon. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H-NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis.
Stereoselective synthesis and conformational analysis of unnatural tetrapeptides. Part 2
BALDUCCI, DANIELE;BOTTONI, ANDREA;CALVARESI, MATTEO;PORZI, GIANNI
2007
Abstract
Stereoselective synthesis of unnatural tetrapeptides containing two L-valine units and two unnatural alpha-amino acids (ornithine and modified aspartic acid), has been accomplished starting from a L-valine derived chiral synthon. Structural investigations of these non-proteinogenic peptides have been carried out on the acetamido derivatives using 1H-NMR, IR spectroscopic techniques and a conformational analysis based on molecular dynamics (MD) and cluster analysis.File in questo prodotto:
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