The stereoselective synthesis of pseudo-heptapeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedioic acid residue, was accomplished starting from a masked unnatural dipeptide derived from an L-valine unit and (2R)-methylaspartic acid. Investigations of the conformational preference and structure of these unnatural peptides were carried out using 1H-NMR and IR spectroscopic data and a conformational analysis based on molecular dynamics (MD).
D. Balducci, A. Bottoni, M. Calvaresi, G. Porzi, S. Sandri (2007). Stereoselective synthesis and conformational analysis of pseudo-heptapeptides. Part 5. TETRAHEDRON-ASYMMETRY, 18, 1448-1456 [10.1016/j.tetasy.2007.06.016].
Stereoselective synthesis and conformational analysis of pseudo-heptapeptides. Part 5
BALDUCCI, DANIELE;BOTTONI, ANDREA;CALVARESI, MATTEO;PORZI, GIANNI;SANDRI, SERGIO
2007
Abstract
The stereoselective synthesis of pseudo-heptapeptides incorporating 2,6-diamino-4-methylen-1,7-heptanedioic acid residue, was accomplished starting from a masked unnatural dipeptide derived from an L-valine unit and (2R)-methylaspartic acid. Investigations of the conformational preference and structure of these unnatural peptides were carried out using 1H-NMR and IR spectroscopic data and a conformational analysis based on molecular dynamics (MD).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
