A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons monolactim ethers derived from L-valine, and the absolute configurations of new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and are inactive towards alpha-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.

Synthesis of new chiral 1,4-morpholin-2,5-dione derivatives and evaluation as alpha-glucosidase inhibitors. Part 3

ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;
2007

Abstract

A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons monolactim ethers derived from L-valine, and the absolute configurations of new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and are inactive towards alpha-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.
2007
A. Arcelli; D. Balducci; S. de Fatima Estevao Neto; G. Porzi; M. Sandri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/52864
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