A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons monolactim ethers derived from L-valine, and the absolute configurations of new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and are inactive towards alpha-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.
A. Arcelli, D. Balducci, S. de Fatima Estevao Neto, G. Porzi, M. Sandri (2007). Synthesis of new chiral 1,4-morpholin-2,5-dione derivatives and evaluation as alpha-glucosidase inhibitors. Part 3. TETRAHEDRON-ASYMMETRY, 18, 562-568 [10.1016/j.tetasy.2007.02.013].
Synthesis of new chiral 1,4-morpholin-2,5-dione derivatives and evaluation as alpha-glucosidase inhibitors. Part 3
ARCELLI, ANTONIO;BALDUCCI, DANIELE;PORZI, GIANNI;
2007
Abstract
A series of chiral 1,4-morpholin-2,5-dione derivatives were synthesized starting from chiral synthons monolactim ethers derived from L-valine, and the absolute configurations of new stereocentres were assigned. The substrates investigated behave as noncompetitive inhibitors against alpha-glucosidases and are inactive towards alpha-glucosidase, alpha-mannosidase and alpha-galactosidase. Three of these substrates show very good and specific inhibition abilities towards alpha-glucosidase.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
