In the last 10 years, there has been a worrisome growing emergence of Enterococcus as a major causative agent of biliary infections. Linezolid is considered to be a valuable antibacterial agent for the treatment of VRE infections, even in the presence of cholangitis. Our group showed that linezolid may, after standard dosages, achieve optimal pharmacodynamic exposure. However, since linezolid is a time-dependent antibacterial agent whose efficacy depends both on the time spent above the MIC (T>MIC) and on the AUC/MIC ratio,6 what remains to be addressed in LTx patients is whether or not linezolid may ensure effective biliary exposure over time in terms of AUC.tment of VRE infections, even in the presence of cholangitis. Our group showed that linezolid may, after standard dosages, achieve optimal pharmacodynamic exposure.
Biliary pharmacodynamic exposure to linezolid in two liver transplant patients
Pea, F. Ab;VIALE, PIERLUIGI
2014
Abstract
In the last 10 years, there has been a worrisome growing emergence of Enterococcus as a major causative agent of biliary infections. Linezolid is considered to be a valuable antibacterial agent for the treatment of VRE infections, even in the presence of cholangitis. Our group showed that linezolid may, after standard dosages, achieve optimal pharmacodynamic exposure. However, since linezolid is a time-dependent antibacterial agent whose efficacy depends both on the time spent above the MIC (T>MIC) and on the AUC/MIC ratio,6 what remains to be addressed in LTx patients is whether or not linezolid may ensure effective biliary exposure over time in terms of AUC.tment of VRE infections, even in the presence of cholangitis. Our group showed that linezolid may, after standard dosages, achieve optimal pharmacodynamic exposure.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.