In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA) metabolites, which activate TRPs, are present in colon tissues from patients with IBS and act as endogenous agonists to induce hypersensitivity.
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome / Cenac, Nicolas; Bautzova, Tereza; Le Faouder, Pauline; Veldhuis, Nicholas A; Poole, Daniel P; Rolland, Corinne; Bertrand, Jessica; Liedtke, Wolfgang; Dubourdeau, Marc; Bertrand-Michel, Justine; Zecchi, Lisa; Stanghellini, Vincenzo; Bunnett, Nigel W; Barbara, Giovanni; Vergnolle, Nathalie. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 149:2(2015), pp. 433-444. [10.1053/j.gastro.2015.04.011]
Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome
ZECCHI, LISA;STANGHELLINI, VINCENZO;BARBARA, GIOVANNI;
2015
Abstract
In mice, activation of the transient receptor potential cation channels (TRP) TRPV1, TRPV4, and TRPA1 causes visceral hypersensitivity. These receptors and their agonists might be involved in development of irritable bowel syndrome (IBS). We investigated whether polyunsaturated fatty acid (PUFA) metabolites, which activate TRPs, are present in colon tissues from patients with IBS and act as endogenous agonists to induce hypersensitivity.| File | Dimensione | Formato | |
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