Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth.
Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome / Dothel, Giovanni; Barbaro, Maria Raffaella; Boudin, Hélène; Vasina, Valentina; Cremon, Cesare; Gargano, Luciana; Bellacosa, Lara; De Giorgio, Roberto; Le Berre-Scoul, Catherine; Aubert, Philippe; Neunlist, Michel; De Ponti, Fabrizio; Stanghellini, Vincenzo; Barbara, Giovanni. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - STAMPA. - 148:5(2015), pp. 1002-1011. [10.1053/j.gastro.2015.01.042]
Nerve fiber outgrowth is increased in the intestinal mucosa of patients with irritable bowel syndrome
DOTHEL, GIOVANNI;BARBARO, MARIA RAFFAELLA;VASINA, VALENTINA;CREMON, CESARE;GARGANO, LUCIANA;BELLACOSA, LARA;DE GIORGIO, ROBERTO;DE PONTI, FABRIZIO;STANGHELLINI, VINCENZO;BARBARA, GIOVANNI
2015
Abstract
Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the phenotypes of colonic mucosa nerve fibers, neuron differentiation, and fiber outgrowth.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
