Skin adverse events associated with D-Penicillamine (DPA) are common and multi-faceted, although the presence of DPA or its metabolites has never been documented in the skin, because of inherent difficulties in determining its tissue levels. Thus, the association between DPA and DPA-related dermatoses has been only hypothesized on the basis of careful history, clinical observation and typical histopathological findings.

Detection of D-penicillamine in skin lesions in a case of dermal elastosis after a previous long-term treatment for Wilson's disease

NERI, IRIA;GURIOLI, CARLOTTA;RAGGI, MARIA AUGUSTA;DE PONTI, FABRIZIO;VACCARI, SABINA;PATRIZI, ANNALISA;BALESTRI, RICCARDO
2015

Abstract

Skin adverse events associated with D-Penicillamine (DPA) are common and multi-faceted, although the presence of DPA or its metabolites has never been documented in the skin, because of inherent difficulties in determining its tissue levels. Thus, the association between DPA and DPA-related dermatoses has been only hypothesized on the basis of careful history, clinical observation and typical histopathological findings.
Neri, I; Gurioli, C; Raggi, M A; Saracino, M A; Morganti, E; Bugamelli, F; de Ponti, F; Vaccari, S; Patrizi, A; Balestri, R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/526535
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