Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, with a median overall survival of less than six months. While most of the genetic mutations occurring in papillary thyroid carcinoma (PTC) were recently discovered through an integrated genomic approach, molecular genetics of ATC is still in part unknown. ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine therapy. New target agents are currently being evaluated in clinical trials. Under this frame, there is an urgent need to investigate the molecular biology and the therapeutic opportunities of this understudied, rare cancer.
Anaplastic Thyroid Carcinoma: Molecular Tools for Diagnosis and Therapy
TALLINI, GIOVANNI;
2015
Abstract
Anaplastic thyroid carcinoma (ATC) is one of the most lethal human malignancies, with a median overall survival of less than six months. While most of the genetic mutations occurring in papillary thyroid carcinoma (PTC) were recently discovered through an integrated genomic approach, molecular genetics of ATC is still in part unknown. ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine therapy. New target agents are currently being evaluated in clinical trials. Under this frame, there is an urgent need to investigate the molecular biology and the therapeutic opportunities of this understudied, rare cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
