The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where gold electrodes are sputtered and by a polydimethylsiloxane microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi-real-time reconstruction of thrombus volume. This is not possible with present state-of-the-art optical imaging based on confocal microscopy, which provides the thrombus volume estimation only at the end of the thrombus formation.
A novel inversion technique for imaging thrombus volume in microchannels fusing optical and impedance data / Affanni, Antonio; Chiorboli, Giovanni; Codecasa, Lorenzo; Cozzi, Maria Rita; De Marco, Luigi; Mazzucato, Moreno; Morandi, Carlo; Specogna, Ruben; Tartagni, Marco; Trevisan, Francesco. - In: IEEE TRANSACTIONS ON MAGNETICS. - ISSN 0018-9464. - STAMPA. - 50:2(2014), pp. 6749262.1021-6749262.1024. [10.1109/TMAG.2013.2281987]
A novel inversion technique for imaging thrombus volume in microchannels fusing optical and impedance data
TARTAGNI, MARCO;
2014
Abstract
The aim of this paper is to present a novel inversion technique to measure the volume of thrombus induced under blood flow conditions in a lab-on-a-chip device. The device is composed by a microscope slide where gold electrodes are sputtered and by a polydimethylsiloxane microchannel placed on the top of the slide. A thrombogenic substance is placed on the slide in such a way that hemostasis is induced when whole blood flows in the microchannel. The novel idea behind the inversion technique is to fuse optical and electrical impedance data to obtain a quasi-real-time reconstruction of thrombus volume. This is not possible with present state-of-the-art optical imaging based on confocal microscopy, which provides the thrombus volume estimation only at the end of the thrombus formation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.