In this paper, a process for generating collagen-yttria-stabilized amorphous zirconia hybrid scaffolds by introducing acetylacetone-inhibited zirconia precursor nanodroplets into a poly(allylamine)-coated collagen matrix is reported. This polyelectrolyte coating triggers intrafibrillar condensation of the precursors into amorphous zirconia, which is subsequently transformed into yttria-stabilized zirconia after calcination. These findings represent a new paradigm in the synthesis of non-naturally occurring collagen-based hybrid scaffolds under alcoholic mineralizing conditions. Acac-stablized yttria-stabilized zirconia (YSZ) nano-sized precursors infuse into the fibril and coalesce in the presence of the PAH-crosslinked collagen molecules to form larger-sized precursor droplets. These precursor droplets further condense in the presence of water available within the intrafibrillar compartments of the collagen fibril into amorphous YSZ nanoparticles. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Adopting the principles of collagen biomineralization for intrafibrillar infiltration of yttria-stabilized zirconia into three-dimensional collagen scaffolds

BRESCHI, LORENZO;
2014

Abstract

In this paper, a process for generating collagen-yttria-stabilized amorphous zirconia hybrid scaffolds by introducing acetylacetone-inhibited zirconia precursor nanodroplets into a poly(allylamine)-coated collagen matrix is reported. This polyelectrolyte coating triggers intrafibrillar condensation of the precursors into amorphous zirconia, which is subsequently transformed into yttria-stabilized zirconia after calcination. These findings represent a new paradigm in the synthesis of non-naturally occurring collagen-based hybrid scaffolds under alcoholic mineralizing conditions. Acac-stablized yttria-stabilized zirconia (YSZ) nano-sized precursors infuse into the fibril and coalesce in the presence of the PAH-crosslinked collagen molecules to form larger-sized precursor droplets. These precursor droplets further condense in the presence of water available within the intrafibrillar compartments of the collagen fibril into amorphous YSZ nanoparticles. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
ADVANCED FUNCTIONAL MATERIALS
Zhou, Bin; Niu, Li-Na; Shi, Wei; Zhang, Wei; Arola, Dwayne D.; Breschi, Lorenzo; Mao, Jing; Chen, Ji-Hua; Pashley, David H.; Tay, Franklin R.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/524088
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