Prostate cancer is a heterogeneous, indolent or sometimes aggressive tumor. Treatment options are various and without proved superiority. Radiotherapy (RT) plays a key role in the disease history. Technological evolution with Intensity Modulate Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT) allowed improvement, with significant results on local control and survival. Hypofractionation, Stereotactic Body RT (SBRT) and new brachytherapy approachs are still under investigation, with promising opportunities. Adjuvant vs salvage postoperative RT, hormone association, prophylactic pelvic irradiation are still under debate, but guidelines express overlapping indications. Multidisciplinary managements will be the future for care optimization, providing the best tool for holistic and informed patients’ choice.
Mantini, G., Alitto, A.r., Fionda, B., Frascino, V., Mattiucci, G.c., Balducci, M., et al. (2013). Radiotherapy in men with prostate cancer: indications, evolutions and integrated approaches [La radioterapia nel trattamento del carcinoma della prostata: indicazioni, evoluzione tecnologica e approcci integrati]. UROLOGIA, 80(3), 188-201 [10.5301/RU.2013.11499].
Radiotherapy in men with prostate cancer: indications, evolutions and integrated approaches [La radioterapia nel trattamento del carcinoma della prostata: indicazioni, evoluzione tecnologica e approcci integrati]
MORGANTI, ALESSIO GIUSEPPE;
2013
Abstract
Prostate cancer is a heterogeneous, indolent or sometimes aggressive tumor. Treatment options are various and without proved superiority. Radiotherapy (RT) plays a key role in the disease history. Technological evolution with Intensity Modulate Radiation Therapy (IMRT) and Image Guided Radiation Therapy (IGRT) allowed improvement, with significant results on local control and survival. Hypofractionation, Stereotactic Body RT (SBRT) and new brachytherapy approachs are still under investigation, with promising opportunities. Adjuvant vs salvage postoperative RT, hormone association, prophylactic pelvic irradiation are still under debate, but guidelines express overlapping indications. Multidisciplinary managements will be the future for care optimization, providing the best tool for holistic and informed patients’ choice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
