The intermolecular a-allylation of enals and enones occurs by the condensation of variously substituted allen- amides with allylic alcohols. Cooperative catalysis by [Au- (ItBu)NTf2] and AgNTf2 enables the synthesis of a range of densely functionalized a-allylated enals, enones, and acyl silanes in good yield under mild reaction conditions. DFT calculations support the role of an a-gold(I) enal/enone as the active nucleophilic species.
Gold(I)-Assisted a-Allylation of Enals and Enones with Alcohols
GIACINTO, PIETRO;MISCIONE, GIAN PIETRO;BOTTONI, ANDREA;BANDINI, MARCO
2015
Abstract
The intermolecular a-allylation of enals and enones occurs by the condensation of variously substituted allen- amides with allylic alcohols. Cooperative catalysis by [Au- (ItBu)NTf2] and AgNTf2 enables the synthesis of a range of densely functionalized a-allylated enals, enones, and acyl silanes in good yield under mild reaction conditions. DFT calculations support the role of an a-gold(I) enal/enone as the active nucleophilic species.File in questo prodotto:
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