Hypocretin/orexin peptides are known for their role in the control of the wake-sleep cycle and narcolepsy-cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy. We tested this hypothesis by conducting a retrospective analysis on pregnancy complications in two different mouse models of hypocretin deficiency. We recorded 85 pregnancies of mice lacking either hypocretin peptides (knockout) or hypocretin-releasing neurons (transgenic) and their wild-type controls. Pregnancy was associated with unexplained dam death before delivery in 3/15 pregnancies in knockout mice, and in 3/23 pregnancies in transgenic mice. No casualties occurred in wild-type pregnant dams (P<0.007 versus hypocretin-deficient mice as a whole). Hypocretin deficiency did not impact either on litter size or the number of weaned pups per litter. These data provide preliminary evidence of a critical role of hypocretin deficiency in pregnancy.
A critical role of hypocretin deficiency in pregnancy / Bastianini, S.; Berteotti, C.; Lo Martire, V.; Silvani, A.; Zoccoli, G.. - In: JOURNAL OF SLEEP RESEARCH. - ISSN 0962-1105. - ELETTRONICO. - 23:2(2014), pp. 186-188. [10.1111/jsr.12107]
A critical role of hypocretin deficiency in pregnancy
BASTIANINI, STEFANO;BERTEOTTI, CHIARA;LO MARTIRE, VIVIANA CARMEN;SILVANI, ALESSANDRO;ZOCCOLI, GIOVANNA
2014
Abstract
Hypocretin/orexin peptides are known for their role in the control of the wake-sleep cycle and narcolepsy-cataplexy pathophysiology. Recent studies suggested that hypocretin peptides also have a role in pregnancy. We tested this hypothesis by conducting a retrospective analysis on pregnancy complications in two different mouse models of hypocretin deficiency. We recorded 85 pregnancies of mice lacking either hypocretin peptides (knockout) or hypocretin-releasing neurons (transgenic) and their wild-type controls. Pregnancy was associated with unexplained dam death before delivery in 3/15 pregnancies in knockout mice, and in 3/23 pregnancies in transgenic mice. No casualties occurred in wild-type pregnant dams (P<0.007 versus hypocretin-deficient mice as a whole). Hypocretin deficiency did not impact either on litter size or the number of weaned pups per litter. These data provide preliminary evidence of a critical role of hypocretin deficiency in pregnancy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
