Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.

Follo, M.Y., Manzoli, L., Poli, A., Mccubrey, J.A., Cocco, L. (2015). PLC and PI3K/Akt/mTOR signalling in disease and cancer. ADVANCES IN BIOLOGICAL REGULATION, 57, 10-16 [10.1016/j.jbior.2014.10.004].

PLC and PI3K/Akt/mTOR signalling in disease and cancer

FOLLO, MATILDE YUNG;MANZOLI, LUCIA;POLI, ALESSANDRO;COCCO, LUCIO ILDEBRANDO
2015

Abstract

Cancer cell metabolism is deregulated, and signalling pathways can be involved. For instance, PI3K/Akt/mTOR is associated with normal proliferation and differentiation, and its alteration is detectable in cancer cells, that exploit the normal mechanisms to overcome apoptosis. On the other hand, also the family of Phospholipase C (PLC) enzymes play a critical role in cell growth, and any change concerning these enzymes or their downstream targets can be associated with neoplastic transformation. Here, we review the role of PLC and PI3K/Akt/mTOR signal transduction pathways in pathophysiology.
2015
Follo, M.Y., Manzoli, L., Poli, A., Mccubrey, J.A., Cocco, L. (2015). PLC and PI3K/Akt/mTOR signalling in disease and cancer. ADVANCES IN BIOLOGICAL REGULATION, 57, 10-16 [10.1016/j.jbior.2014.10.004].
Follo, Matilde Y; Manzoli, Lucia; Poli, Alessandro; Mccubrey, James A.; Cocco, Lucio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/521088
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