Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.

DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy

Fabbri, C.;SERRETTI, ALESSANDRO;
2014

Abstract

Major depressive disorder (MDD) is a common disease with high morbidity and still unsatisfying treatment response. Both MDD pathogenesis and antidepressant effect are supposed to be strongly affected by genetic polymorphisms. Among promising candidate genes, distrupted in schizophrenia 1 (DISC1), translin-associated factor X (TSNAX) and D-amino acid oxidase activator (DAOA) were suggested since their regulator role in neurodevelopment, neuroplasticity and neurotransmission, and previous evidence of cross-involvement in major psychiatric diseases.
JOURNAL OF AFFECTIVE DISORDERS
Arias, B.; Fabbri, C.; Serretti, A.; Drago, A.; Mitjans, M.; Gasto, C.; Catalan, R.; Fananas, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/519851
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