The frequent occurrence of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline ring systems in a large number of alkaloids, possessing a broad spectrum of biological and pharmaceutical properties, has prompted out a considerable interest in their synthesis. Economical and valuable stereoselective processes based on organocatalytic transformations represent a new avenue for approaching isoquinoline alkaloids with efficiency and creativity.

Gualandi, A., Mengozzi, L., Manoni, E., Cozzi, P.G. (2015). Stereoselective Organocatalytic Addition of Nucleophiles to Isoquinolinium and 3,4-dihydroisoquinolinium Ions: A Simple Approach for the Synthesis of Isoquinoline Alkaloids. CATALYSIS LETTERS, 145(1), 398-419 [10.1007/s10562-014-1396-0].

Stereoselective Organocatalytic Addition of Nucleophiles to Isoquinolinium and 3,4-dihydroisoquinolinium Ions: A Simple Approach for the Synthesis of Isoquinoline Alkaloids

GUALANDI, ANDREA;MENGOZZI, LUCA;MANONI, ELISABETTA;COZZI, PIER GIORGIO
2015

Abstract

The frequent occurrence of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline ring systems in a large number of alkaloids, possessing a broad spectrum of biological and pharmaceutical properties, has prompted out a considerable interest in their synthesis. Economical and valuable stereoselective processes based on organocatalytic transformations represent a new avenue for approaching isoquinoline alkaloids with efficiency and creativity.
2015
Gualandi, A., Mengozzi, L., Manoni, E., Cozzi, P.G. (2015). Stereoselective Organocatalytic Addition of Nucleophiles to Isoquinolinium and 3,4-dihydroisoquinolinium Ions: A Simple Approach for the Synthesis of Isoquinoline Alkaloids. CATALYSIS LETTERS, 145(1), 398-419 [10.1007/s10562-014-1396-0].
Gualandi, Andrea; Mengozzi, Luca; Manoni, Elisabetta; Cozzi, Pier Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/519290
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