Provide an enhanced local drug delivery, nanoparticle(s) to minimize systemic effects and achieve enhanced permeability and drug retention into abnormal cells and stroma. Materials & methods: Here a simultaneous loading of lipophilic gold nanorods (GNRs) and curcumin into polymeric nanomicelles made of biocompatible PLGA-b-PEG copolymer through a double re-emulsification process has been developed. Results: Initial results in vitro on Barrett’s esophagus and esophageal adenocarcinoma cell lines demonstrated a significant reduction in cell viability with curcumin and GNRs exposure (p < 0.05). In vivo Barrett’s-associated animal model confirmed these results with successful in vivo demonstrated eradication of all highgrade dysplastic premalignant cancer cells. Conclusion: The synthesis of this novel nanosystem containing GNRs and curcumin is safe and effective in treating and eradicating premalignant esophageal adenocarcinoma.

Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus / Martin, Robert C.G; Locatelli, Erica; Li, Yan; Zhang, Weizhong; Li, Suping; Monaco, Ilaria; Comes Franchini, Mauro. - In: NANOMEDICINE. - ISSN 1743-5889. - STAMPA. - 10:11(2015), pp. 1723-1733. [10.2217/nnm.15.25]

Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus

LOCATELLI, ERICA;MONACO, ILARIA;COMES FRANCHINI, MAURO
2015

Abstract

Provide an enhanced local drug delivery, nanoparticle(s) to minimize systemic effects and achieve enhanced permeability and drug retention into abnormal cells and stroma. Materials & methods: Here a simultaneous loading of lipophilic gold nanorods (GNRs) and curcumin into polymeric nanomicelles made of biocompatible PLGA-b-PEG copolymer through a double re-emulsification process has been developed. Results: Initial results in vitro on Barrett’s esophagus and esophageal adenocarcinoma cell lines demonstrated a significant reduction in cell viability with curcumin and GNRs exposure (p < 0.05). In vivo Barrett’s-associated animal model confirmed these results with successful in vivo demonstrated eradication of all highgrade dysplastic premalignant cancer cells. Conclusion: The synthesis of this novel nanosystem containing GNRs and curcumin is safe and effective in treating and eradicating premalignant esophageal adenocarcinoma.
2015
Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus / Martin, Robert C.G; Locatelli, Erica; Li, Yan; Zhang, Weizhong; Li, Suping; Monaco, Ilaria; Comes Franchini, Mauro. - In: NANOMEDICINE. - ISSN 1743-5889. - STAMPA. - 10:11(2015), pp. 1723-1733. [10.2217/nnm.15.25]
Martin, Robert C.G; Locatelli, Erica; Li, Yan; Zhang, Weizhong; Li, Suping; Monaco, Ilaria; Comes Franchini, Mauro
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/516618
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