OBJECTIVE: To assess in a cohort of twin pregnancies the prevalence of obstetric cholestasis (OC) and its correlation with the type of conception and chorionicity. METHODS: A retrospective cohort study including all the twin pregnancies delivered between 2005 and 2013 at our University Hospital was carried out. In the study population, the prevalence of OC was investigated in relationship to the impact of assisted reproductive technology (ART) and of chorionicity. RESULTS: Overall, 569 twin pregnancies were included in the study population. Among those complicated by OC, the rate of ART was 3-fold higher (OR 3.4, 95% CI 1.2-9.5, p = 0.02), whereas the rate of dichorionicity did not differ significantly (OR 1.6, 95% CI 0.3-7.9, p = 0.53). CONCLUSION: The risk of developing OC seems to be significantly higher among twin pregnancies obtained after ART in comparison with those conceived spontaneously.

The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis

Ginevra Salsi;FARINA, ANTONIO;BACCHI REGGIANI, MARIA LETIZIA;Federica Bellussi;MAZZELLA, GIUSEPPE;AZZAROLI, FRANCESCO;PORCU, ELEONORA;RIZZO, NICOLA;GHI, TULLIO
2016

Abstract

OBJECTIVE: To assess in a cohort of twin pregnancies the prevalence of obstetric cholestasis (OC) and its correlation with the type of conception and chorionicity. METHODS: A retrospective cohort study including all the twin pregnancies delivered between 2005 and 2013 at our University Hospital was carried out. In the study population, the prevalence of OC was investigated in relationship to the impact of assisted reproductive technology (ART) and of chorionicity. RESULTS: Overall, 569 twin pregnancies were included in the study population. Among those complicated by OC, the rate of ART was 3-fold higher (OR 3.4, 95% CI 1.2-9.5, p = 0.02), whereas the rate of dichorionicity did not differ significantly (OR 1.6, 95% CI 0.3-7.9, p = 0.53). CONCLUSION: The risk of developing OC seems to be significantly higher among twin pregnancies obtained after ART in comparison with those conceived spontaneously.
Giuseppina Pacella; Ginevra Salsi; Tiziana Arcangeli; Aly Youssef; Antonio Farina; Maria Letizia Bacchi-Reggiani; Federica Bellussi; Giuseppe Mazzella; Francesco Azzaroli; Eleonora Porcu; Nicola Rizzo; Tullio Ghi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/515542
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