OBJECTIVE: To assess in a cohort of twin pregnancies the prevalence of obstetric cholestasis (OC) and its correlation with the type of conception and chorionicity. METHODS: A retrospective cohort study including all the twin pregnancies delivered between 2005 and 2013 at our University Hospital was carried out. In the study population, the prevalence of OC was investigated in relationship to the impact of assisted reproductive technology (ART) and of chorionicity. RESULTS: Overall, 569 twin pregnancies were included in the study population. Among those complicated by OC, the rate of ART was 3-fold higher (OR 3.4, 95% CI 1.2-9.5, p = 0.02), whereas the rate of dichorionicity did not differ significantly (OR 1.6, 95% CI 0.3-7.9, p = 0.53). CONCLUSION: The risk of developing OC seems to be significantly higher among twin pregnancies obtained after ART in comparison with those conceived spontaneously.
The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis / Giuseppina Pacella; Ginevra Salsi; Tiziana Arcangeli; Aly Youssef; Antonio Farina; Maria Letizia Bacchi-Reggiani; Federica Bellussi; Giuseppe Mazzella; Francesco Azzaroli; Eleonora Porcu; Nicola Rizzo; Tullio Ghi. - In: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. - ISSN 1476-7058. - STAMPA. - 29:9(2016), pp. 1481-1484. [10.3109/14767058.2015.1051954]
The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis
Ginevra Salsi;FARINA, ANTONIO;BACCHI REGGIANI, MARIA LETIZIA;Federica Bellussi;MAZZELLA, GIUSEPPE;AZZAROLI, FRANCESCO;PORCU, ELEONORA;RIZZO, NICOLA;GHI, TULLIO
2016
Abstract
OBJECTIVE: To assess in a cohort of twin pregnancies the prevalence of obstetric cholestasis (OC) and its correlation with the type of conception and chorionicity. METHODS: A retrospective cohort study including all the twin pregnancies delivered between 2005 and 2013 at our University Hospital was carried out. In the study population, the prevalence of OC was investigated in relationship to the impact of assisted reproductive technology (ART) and of chorionicity. RESULTS: Overall, 569 twin pregnancies were included in the study population. Among those complicated by OC, the rate of ART was 3-fold higher (OR 3.4, 95% CI 1.2-9.5, p = 0.02), whereas the rate of dichorionicity did not differ significantly (OR 1.6, 95% CI 0.3-7.9, p = 0.53). CONCLUSION: The risk of developing OC seems to be significantly higher among twin pregnancies obtained after ART in comparison with those conceived spontaneously.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
