An organocatalytic enantioselective synthesis of a-methylene-g-lactams has been developed. The reaction between protected 2-aminomalonates and MoritaeBayliseHillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.
Companyo, X., Geant, P., Mazzanti, A., Moyano, A., Rios, R. (2014). Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams. TETRAHEDRON, 70(1), 75-82 [10.1016/j.tet.2013.11.028].
Catalytic asymmetric one-pot synthesis of α-methylene-γ-lactams
MAZZANTI, ANDREA;
2014
Abstract
An organocatalytic enantioselective synthesis of a-methylene-g-lactams has been developed. The reaction between protected 2-aminomalonates and MoritaeBayliseHillman carbonates is catalyzed by chiral Lewis bases to afford the corresponding lactams in excellent yields and moderate to good enantioselectivities, after work-up.File in questo prodotto:
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