We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing cell vaccine. Since IL-12 can induce the release of interleukin-15 (IL-15), in the present study we investigated the role played by IL-15 in HER2/neu driven mammary carcinogenesis and in its immunoprevention.
Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis / Croci, S.; Nanni, P.; Palladini, A.; Nicoletti, G.; Grosso, V.; Benegiamo, G.; Landuzzi, L.; Lamolinara, A.; Ianzano, M.L.; Ranieri, D.; Dall'Ora, M.; Iezzi, M.; De Giovanni, C.; Lollini, P.-L.. - In: BREAST CANCER RESEARCH. - ISSN 1465-5411. - ELETTRONICO. - 17:(2015), pp. 70.1-70.13. [10.1186/s13058-015-0588-x]
Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis
CROCI, STEFANIA;NANNI, PATRIZIA;PALLADINI, ARIANNA;GROSSO, VALENTINA;IANZANO, MARIANNA LUCIA;DALL'ORA, MASSIMILIANO;DE GIOVANNI, CARLA
;LOLLINI, PIER LUIGI
2015
Abstract
We previously demonstrated that HER2/neu-driven mammary carcinogenesis can be prevented by an interleukin-12 (IL-12)-adjuvanted allogeneic HER2/neu-expressing cell vaccine. Since IL-12 can induce the release of interleukin-15 (IL-15), in the present study we investigated the role played by IL-15 in HER2/neu driven mammary carcinogenesis and in its immunoprevention.| File | Dimensione | Formato | |
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