Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future.

Lollini, P., Cavallo, F., Nanni, P., Quaglino, E. (2015). The Promise of Preventive Cancer Vaccines. VACCINES, 3(2), 467-489 [10.3390/vaccines3020467].

The Promise of Preventive Cancer Vaccines

LOLLINI, PIER LUIGI;NANNI, PATRIZIA;
2015

Abstract

Years of unsuccessful attempts at fighting established tumors with vaccines have taught us all that they are only able to truly impact patient survival when used in a preventive setting, as would normally be the case for traditional vaccines against infectious diseases. While true primary cancer prevention is still but a long-term goal, secondary and tertiary prevention are already in the clinic and providing encouraging results. A combination of immunopreventive cancer strategies and recently approved checkpoint inhibitors is a further promise of forthcoming successful cancer disease control, but prevention will require a considerable reduction of currently reported toxicities. These considerations summed with the increased understanding of tumor antigens allow space for an optimistic view of the future.
2015
Lollini, P., Cavallo, F., Nanni, P., Quaglino, E. (2015). The Promise of Preventive Cancer Vaccines. VACCINES, 3(2), 467-489 [10.3390/vaccines3020467].
Lollini, Pier-Luigi; Cavallo, Federica; Nanni, Patrizia; Quaglino, Elena
File in questo prodotto:
File Dimensione Formato  
vaccines-03-00467.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione 403.54 kB
Formato Adobe PDF
403.54 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/515057
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 30
social impact