Peripheral T-cell lymphoma unspecified (PTCL/U) is a rare tumor characterized by poor treatment response and a dismal prognosis. We studied CD52 expression in 97 PTCL/U cases by immunohistochemistry on tissue-microarrays. Furthermore, CD52 gene expression was studied in 28 cases for which RNA was available. We found that CD52 is expressed in approximately 40% of PTCLs/U at the same level as in normal T-lymphocytes. Although other factors may play a role in the in vivo response to alemtuzumab, an anti-CD52 monoclonal antibody, the estimation of CD52 expression may provide a rationale for the selection of patients with a higher probability of treatment response.

Expression of CD52 in peripheral T-cell lymphoma / Piccaluga PP; Agostinelli C; Righi S; Zinzani PL; Pileri SA.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 92:(2007), pp. 566-567. [10.3324/haematol.10767]

Expression of CD52 in peripheral T-cell lymphoma.

PICCALUGA, PIER PAOLO;AGOSTINELLI, CLAUDIO;ZINZANI, PIER LUIGI;Pileri S.A.
2007

Abstract

Peripheral T-cell lymphoma unspecified (PTCL/U) is a rare tumor characterized by poor treatment response and a dismal prognosis. We studied CD52 expression in 97 PTCL/U cases by immunohistochemistry on tissue-microarrays. Furthermore, CD52 gene expression was studied in 28 cases for which RNA was available. We found that CD52 is expressed in approximately 40% of PTCLs/U at the same level as in normal T-lymphocytes. Although other factors may play a role in the in vivo response to alemtuzumab, an anti-CD52 monoclonal antibody, the estimation of CD52 expression may provide a rationale for the selection of patients with a higher probability of treatment response.
2007
Expression of CD52 in peripheral T-cell lymphoma / Piccaluga PP; Agostinelli C; Righi S; Zinzani PL; Pileri SA.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 92:(2007), pp. 566-567. [10.3324/haematol.10767]
Piccaluga PP; Agostinelli C; Righi S; Zinzani PL; Pileri SA.
File in questo prodotto:
File Dimensione Formato  
566.full.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Condividi allo stesso modo (CCBYNCSA)
Dimensione 5.58 MB
Formato Adobe PDF
5.58 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/51398
Citazioni
  • ???jsp.display-item.citation.pmc??? 11
  • Scopus 64
  • ???jsp.display-item.citation.isi??? 43
social impact