An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved
Paola, G., Federica, F., Roberto, S., Daria, G. (2015). Selective Oxidation of Amines to Aldehydes or Imines using Laccase-Mediated Bio-Oxidation. ADVANCED SYNTHESIS & CATALYSIS, 357(8), 1840-1848 [10.1002/adsc.201500165].
Selective Oxidation of Amines to Aldehydes or Imines using Laccase-Mediated Bio-Oxidation
Paola Galletti;Roberto Soldati;Daria Giacomini
2015
Abstract
An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved| File | Dimensione | Formato | |
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