An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved

Selective Oxidation of Amines to Aldehydes or Imines using Laccase-Mediated Bio-Oxidation

Paola Galletti;Roberto Soldati;Daria Giacomini
2015

Abstract

An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved
2015
Paola, Galletti; Federica, Funiciello; Roberto, Soldati; Daria, Giacomini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/512766
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