We describe a potentiometric sensor based on Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) for "in vitro'' detection of dopamine. The sensing element of this device resides at the Au gate-aqueous solution interface by means of a self-assembled monolayer (SAM) composed by cysteamine and 4-formylphenyl boronic acid. The covalent and selective adsorption of dopamine induces a surface dipole potential which shifts the electrode work function and modulates the double layer capacitance. As a result, our device is capable to detect dopamine up to pico-molar concentration showing higher sensitivity with respect to other approaches. For this reason the interface engineering of our EGOFET gate is a promising route for diagnostic applications. (c) 2012 Elsevier B.V. All rights reserved.

Organic field-effect transistor for label-free dopamine sensing

LEONARDI, FRANCESCA;CRAMER, TOBIAS;
2013

Abstract

We describe a potentiometric sensor based on Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) for "in vitro'' detection of dopamine. The sensing element of this device resides at the Au gate-aqueous solution interface by means of a self-assembled monolayer (SAM) composed by cysteamine and 4-formylphenyl boronic acid. The covalent and selective adsorption of dopamine induces a surface dipole potential which shifts the electrode work function and modulates the double layer capacitance. As a result, our device is capable to detect dopamine up to pico-molar concentration showing higher sensitivity with respect to other approaches. For this reason the interface engineering of our EGOFET gate is a promising route for diagnostic applications. (c) 2012 Elsevier B.V. All rights reserved.
2013
Stefano Casalini;Francesca Leonardi;Tobias Cramer;Fabio Biscarini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/511805
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