Mimicking the hierarchical self-assembly observed in nature has long been recognised as a powerful strategy for bottom-up fabrication of sophisticated functional nanoarchitectures. This lecture describes some recent advances in the form and function provided by self-assembly of guanine (G) based systems. The presentation begins with a brief historical context of G self-assembly in water and then describes studies on lipophilic guanosine analogs in organic solvents. Depending on the experimental conditions, lipophilic guanosines can undergo different self-assembly pathways. Notably, the presence of monovalent and divalent cations can template the formation of G-quadruplex-based octamers or columnar aggregates, depending on the concentration of the ion and nucleobase. These chiral, columnar structures may self-correlate to give a liquid crystalline order. In the absence of metal templates, guanosines (without a C-8 substituent) self-assemble, both in solution and in the solid state, into ribbon-like architectures possibly leading to lyotropic mesophases. The lecture also focuses on a few examples of how G analogs have been used as building blocks for functional applications in supramolecular chemistry, material science and nanotechnology.

THE STEPWISE SUPRAMOLECULAR ORGANISATION OF GUANOSINE DERIVATIVES (invited plenary lecture) / G. P. Spada. - STAMPA. - (2007), pp. 17-17. (Intervento presentato al convegno International Conference Chirality at the Nanoscale tenutosi a Sitges, Barcelona (Spain) nel 17-21 September 2007).

THE STEPWISE SUPRAMOLECULAR ORGANISATION OF GUANOSINE DERIVATIVES (invited plenary lecture)

SPADA, GIAN PIERO
2007

Abstract

Mimicking the hierarchical self-assembly observed in nature has long been recognised as a powerful strategy for bottom-up fabrication of sophisticated functional nanoarchitectures. This lecture describes some recent advances in the form and function provided by self-assembly of guanine (G) based systems. The presentation begins with a brief historical context of G self-assembly in water and then describes studies on lipophilic guanosine analogs in organic solvents. Depending on the experimental conditions, lipophilic guanosines can undergo different self-assembly pathways. Notably, the presence of monovalent and divalent cations can template the formation of G-quadruplex-based octamers or columnar aggregates, depending on the concentration of the ion and nucleobase. These chiral, columnar structures may self-correlate to give a liquid crystalline order. In the absence of metal templates, guanosines (without a C-8 substituent) self-assemble, both in solution and in the solid state, into ribbon-like architectures possibly leading to lyotropic mesophases. The lecture also focuses on a few examples of how G analogs have been used as building blocks for functional applications in supramolecular chemistry, material science and nanotechnology.
2007
Chirality at the Nanoscale
17
17
THE STEPWISE SUPRAMOLECULAR ORGANISATION OF GUANOSINE DERIVATIVES (invited plenary lecture) / G. P. Spada. - STAMPA. - (2007), pp. 17-17. (Intervento presentato al convegno International Conference Chirality at the Nanoscale tenutosi a Sitges, Barcelona (Spain) nel 17-21 September 2007).
G. P. Spada
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/51093
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