Background: Increased serumuric acid has been considered a cardiovascular risk factor but no study has assessed its relationwith hospitalmortality or length of stay. On the basis of data obtained froma prospective registry, the prevalence of gout/hyperuricemia and its association with these and other clinical parameters was evaluated in an Italian cohort of elderly patients acutely admitted to internal medicine or geriatric wards. Methods: While the prevalence of gout was calculated by counting patients with this diagnosis hyperuricemia was inferred in patients taking allopurinol at hospital admission or discharge, on the assumption that this drug was only prescribed owing to the finding of high serum levels of uric acid. A series of clinical and demographic variables were evaluated for their association with gout/hyperuricemia. Results: Of 1380 patients, 139 (10%) had a diagnosis of gout or were prescribed allopurinol. They had more co-morbidities (7.0 vs 5.6; P b 0.0001) and consumedmore drugs (6.8 vs 5.0; P b 0.0001). The CIRS (co-morbidity index) was worse in these patients (OR 1.28 95% CI 1.15–1.41). Multivariable regression analysis showed that only renal and heart failures were independently associated with gout/allopurinol intake. Moreover, this combined event was associated with an increased risk of adverse events during hospitalization (OR 1.66, 95% CI 1.16–2.36), but not with the risk of re-hospitalization, length of hospital stay or death. Conclusions: Gout/allopurinol intake has a high prevalence in elderly patients acutely admitted to hospital and are associated with renal and cardiovascular diseases, an increased rate of adverse events and a high degree

Gout, allopurinol intake and clinical outcomes in the hospitalized multimorbid elderly.

BERNARDI, MAURO;BORGHI, CLAUDIO;STROCCHI, ENRICO;ZOLI, MARCO;BOLONDI, LUIGI;CORINALDESI, ROBERTO;DE GIORGIO, ROBERTO
2014

Abstract

Background: Increased serumuric acid has been considered a cardiovascular risk factor but no study has assessed its relationwith hospitalmortality or length of stay. On the basis of data obtained froma prospective registry, the prevalence of gout/hyperuricemia and its association with these and other clinical parameters was evaluated in an Italian cohort of elderly patients acutely admitted to internal medicine or geriatric wards. Methods: While the prevalence of gout was calculated by counting patients with this diagnosis hyperuricemia was inferred in patients taking allopurinol at hospital admission or discharge, on the assumption that this drug was only prescribed owing to the finding of high serum levels of uric acid. A series of clinical and demographic variables were evaluated for their association with gout/hyperuricemia. Results: Of 1380 patients, 139 (10%) had a diagnosis of gout or were prescribed allopurinol. They had more co-morbidities (7.0 vs 5.6; P b 0.0001) and consumedmore drugs (6.8 vs 5.0; P b 0.0001). The CIRS (co-morbidity index) was worse in these patients (OR 1.28 95% CI 1.15–1.41). Multivariable regression analysis showed that only renal and heart failures were independently associated with gout/allopurinol intake. Moreover, this combined event was associated with an increased risk of adverse events during hospitalization (OR 1.66, 95% CI 1.16–2.36), but not with the risk of re-hospitalization, length of hospital stay or death. Conclusions: Gout/allopurinol intake has a high prevalence in elderly patients acutely admitted to hospital and are associated with renal and cardiovascular diseases, an increased rate of adverse events and a high degree
2014
337. Franchi C; Salerno F; Conca A; Djade CD; Tettamanti M; Pasina L; Corrao S; Marengoni A; Marcucci M; Mannucci PM; Nobili A. REPOSI Investigators; Bernardi M; Borghi C; Strocchi E; Zoli M; Bolondi L; Corinaldesi R; De Giorgio R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/508567
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