Bioresorbable new terpolymers of L-lactide, glycolide and trimethylene carbonate with different composition were synthesized via ring opening polymerization reaction of the cyclic monomers using low-toxicity zirconium (IV) acetylacetonate as initiator. The thermal and mechanical properties were investigated by means of thermogravimetry, differential scanning calorimetry, stress-strain measurements and dynamical mechanical analysis. The glass transition temperature of the terpolymers changes with composition from 12°C to 42°C in a predictable manner. All terpolymers display shape memory properties and, after undergoing 100% deformation, they recover the permanent shape in a time frame of seconds. Terpolymers with high L-lactide content show a glass transition in the range 38-42°C, recovery temperature close to body temperature and good recovery ratio (> 0.89). Low toxicity bioresorbable terpolymers with shape memory properties are promising new materials for biomedical applications
Novel (L-lactide-glycolide-trimethylene carbonate) terpolymers with shape memory properties / E. Zini; M. Scandola; P. Dobrzynski; J. Kasperczyk; M. Bero. - In: BIOMACROMOLECULES. - ISSN 1525-7797. - STAMPA. - 8:(2007), pp. 3661-3667. [10.1021/bm700773s]
Novel (L-lactide-glycolide-trimethylene carbonate) terpolymers with shape memory properties
ZINI, ELISA;SCANDOLA, MARIASTELLA;
2007
Abstract
Bioresorbable new terpolymers of L-lactide, glycolide and trimethylene carbonate with different composition were synthesized via ring opening polymerization reaction of the cyclic monomers using low-toxicity zirconium (IV) acetylacetonate as initiator. The thermal and mechanical properties were investigated by means of thermogravimetry, differential scanning calorimetry, stress-strain measurements and dynamical mechanical analysis. The glass transition temperature of the terpolymers changes with composition from 12°C to 42°C in a predictable manner. All terpolymers display shape memory properties and, after undergoing 100% deformation, they recover the permanent shape in a time frame of seconds. Terpolymers with high L-lactide content show a glass transition in the range 38-42°C, recovery temperature close to body temperature and good recovery ratio (> 0.89). Low toxicity bioresorbable terpolymers with shape memory properties are promising new materials for biomedical applicationsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
