Objective: Generic Quality-of-life (QoL) instruments allow to compare QoL in populations different for culture, languages, health. If utilities are derivable, QoL data can be used in economic research. Unfortunately children often remain excluded from being part of these populations, hence information for optimal decision-making in pediatric context can be limited. The Child-Task-Force operating within the EuroQoL group is translating and validating a Child EQ-5D version. Within the Child-Task-Force, the Italian team conducted a validation study involving 8-15 years old children in Italy. Methods: Children from general population were enrolled at schools, those with chronic diseases enrolled at hospitals. Participants self-completed a core-set containing: EQ-5D(child), Italian version; open-questions on reasons why they reported “no”, “some”, “a lot of” problems with each EQ-5D-domain; standard measures for comparisons (PEDsQL, a scale to self-rate their own global health, the World-Health-Organization health scale), questions on demographic, socio-economic, health status. After 10 days some kids underwent to a re-test interview. Convergent and Discriminant validities were tested by computing correlation coefficients between every couple of items or scores, as appropriate; concurrent validity was tested by comparing the EQ-5D(child) responses of chronically sick versus general population children; reliability was tested by calculating agreement levels of test with re-test responses. Results: 415 valid children from schools (31.1% were re-tested), 11 Acute Linfoblastic Leukaemia patients form hospitals were enrolled. Relevant Spearman’s correlation coefficients (>0.2, p<0.0001) were found between every conceptually similar items/scores; not significant coefficients were found between most of not conceptually similar items. Weighted Cohen’s Kappas were 0.2-0.5 in the profile items. Intraclass-Correlation-Coefficient for VAS=0.715. Leukaemia patients more frequently reported problems/trouble in every EQ-5D item, VAS lower median (92.5 vs 98.0) and mean (83.0 vs 93.9). Conclusions. EQ-5D(child) shows acceptable levels of validity and reliability. Further research will be invested to improve its properties and allow an appropriate use in clinical, economic research and practice
Convergent, discriminant, concurrent validity and reliability of the EQ-5D (child): results / Scalone L.; Cavrini G.; Broccoli S.; Borghetti F.; Pacelli B.; Matteucci M.C.; Tomasetto C.; Selleri P.. - In: VALUE IN HEALTH. - ISSN 1098-3015. - ELETTRONICO. - 10(6):(2007), pp. A455-A455. (Intervento presentato al convegno ISPOR 10th Annual European Congress tenutosi a Dublin, Ireland. nel 20-23 October 2007).
Convergent, discriminant, concurrent validity and reliability of the EQ-5D (child): results
CAVRINI, GIULIA;MATTEUCCI, MARIA CRISTINA;TOMASETTO, CARLO;SELLERI, PATRIZIA
2007
Abstract
Objective: Generic Quality-of-life (QoL) instruments allow to compare QoL in populations different for culture, languages, health. If utilities are derivable, QoL data can be used in economic research. Unfortunately children often remain excluded from being part of these populations, hence information for optimal decision-making in pediatric context can be limited. The Child-Task-Force operating within the EuroQoL group is translating and validating a Child EQ-5D version. Within the Child-Task-Force, the Italian team conducted a validation study involving 8-15 years old children in Italy. Methods: Children from general population were enrolled at schools, those with chronic diseases enrolled at hospitals. Participants self-completed a core-set containing: EQ-5D(child), Italian version; open-questions on reasons why they reported “no”, “some”, “a lot of” problems with each EQ-5D-domain; standard measures for comparisons (PEDsQL, a scale to self-rate their own global health, the World-Health-Organization health scale), questions on demographic, socio-economic, health status. After 10 days some kids underwent to a re-test interview. Convergent and Discriminant validities were tested by computing correlation coefficients between every couple of items or scores, as appropriate; concurrent validity was tested by comparing the EQ-5D(child) responses of chronically sick versus general population children; reliability was tested by calculating agreement levels of test with re-test responses. Results: 415 valid children from schools (31.1% were re-tested), 11 Acute Linfoblastic Leukaemia patients form hospitals were enrolled. Relevant Spearman’s correlation coefficients (>0.2, p<0.0001) were found between every conceptually similar items/scores; not significant coefficients were found between most of not conceptually similar items. Weighted Cohen’s Kappas were 0.2-0.5 in the profile items. Intraclass-Correlation-Coefficient for VAS=0.715. Leukaemia patients more frequently reported problems/trouble in every EQ-5D item, VAS lower median (92.5 vs 98.0) and mean (83.0 vs 93.9). Conclusions. EQ-5D(child) shows acceptable levels of validity and reliability. Further research will be invested to improve its properties and allow an appropriate use in clinical, economic research and practiceI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
