We have studied the non-thermal effects of radiofrequency (RF) electromagnetic fields (EMFs) on Ba2+ currents (IBa2+) through voltage-gated calcium channels (VGCC), recorded in primary cultures of rat cortical neurons using the patch-clamp technique. To assess whether lowlevel acute RF field exposure could modify the amplitude and/or the voltage-dependence of IBa2+, Petri dishes containing cultured neurons were exposed for 1-3 periods of 90 s to 900 MHz RFEMF continuous wave (CW) or amplitude-modulated according to global system mobile communication standard (GSM) during whole-cell recording. The specific absorption rates (SARs) were 2 W/kg for CW, and 2 W/kg (time average value) for GSM-modulated signals, respectively. The results obtained indicate that single or multiple acute exposures to either CW or GSM-modulated 900 MHz RF-EMFs do not significantly alter the current amplitude or the current-voltage relationship of IBa2+, through VGCC.
D. Platano, P. Mesirca, A. Paffi, M. Pellegrino, M. Liberti, F. Apollonio, et al. (2007). Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba(2+) currents through voltage-gated calcium channels in rat cortical neurons. BIOELECTROMAGNETICS, 28, 599-607 [10.1002/bem.20345].
Acute exposure to low-level CW and GSM-modulated 900 MHz radiofrequency does not affect Ba(2+) currents through voltage-gated calcium channels in rat cortical neurons.
PLATANO, DANIELA;MESIRCA, PIETRO;BERSANI, FERDINANDO;AICARDI, GIORGIO
2007
Abstract
We have studied the non-thermal effects of radiofrequency (RF) electromagnetic fields (EMFs) on Ba2+ currents (IBa2+) through voltage-gated calcium channels (VGCC), recorded in primary cultures of rat cortical neurons using the patch-clamp technique. To assess whether lowlevel acute RF field exposure could modify the amplitude and/or the voltage-dependence of IBa2+, Petri dishes containing cultured neurons were exposed for 1-3 periods of 90 s to 900 MHz RFEMF continuous wave (CW) or amplitude-modulated according to global system mobile communication standard (GSM) during whole-cell recording. The specific absorption rates (SARs) were 2 W/kg for CW, and 2 W/kg (time average value) for GSM-modulated signals, respectively. The results obtained indicate that single or multiple acute exposures to either CW or GSM-modulated 900 MHz RF-EMFs do not significantly alter the current amplitude or the current-voltage relationship of IBa2+, through VGCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
